Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain†

نویسندگان

  • Jinmyoung Joo
  • Ester J. Kwon
  • Jinyoung Kang
  • Matthew Skalak
  • Emily J. Anglin
  • Aman P. Mann
  • Erkki Ruoslahti
  • Sangeeta N. Bhatia
  • Michael J. Sailor
چکیده

The delivery of therapeutics based on RNA interference to diseased or damaged tissues in the body is a significant challenge, and the privileged tissues of the brain are among the most difficult to target. By encapsulating the RNA-based therapeutic within a hollow silicon nanoparticle coated with a thin shell of graphene oxide, the sensitive oligonucleotide can be protected from in vivo degradation processes until its delivery to the cells. Tissue-specific targeting molecules can readily be incorporated onto the exterior of the nanoparticle construct in the present case, and a peptide is used to effectively localize the nanoparticle–siRNA construct to the site of injury in a mouse brain.

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تاریخ انتشار 2016