Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain†
نویسندگان
چکیده
The delivery of therapeutics based on RNA interference to diseased or damaged tissues in the body is a significant challenge, and the privileged tissues of the brain are among the most difficult to target. By encapsulating the RNA-based therapeutic within a hollow silicon nanoparticle coated with a thin shell of graphene oxide, the sensitive oligonucleotide can be protected from in vivo degradation processes until its delivery to the cells. Tissue-specific targeting molecules can readily be incorporated onto the exterior of the nanoparticle construct in the present case, and a peptide is used to effectively localize the nanoparticle–siRNA construct to the site of injury in a mouse brain.
منابع مشابه
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